Discussions that mention salsalate

Thyroid Disorders board

[quote]I never drank, and don't take acetemenophin but do take aspirin for this painful arm and shoulder. Same thing

No, not the same Acetaminophen is largely metabolized by the liver and large doses of it or taking it constantly can compromise liver function, therefore impairing T4 to T3 conversion. Aspirin on the other hand does not do this...at least not by the same mechanisms.

Here's a quote from another site I can't link to:

[quote]Treatment for one week with aspirin or salsalate decreased total T4, free T4 (salsalate only), total T3, free T3, and TSH. Thus, this study confirms that aspirin, salsalate, and meclofenamate affect total and free thyroid hormone measurements.

It also demonstrated that three NSAIDs (ibuprofen, naproxen, and indomethacin) do not alter thyroid tests. During the acute (one dose) and on week administration of these NSAIDs TSH levels remained with the normal range.