I LOVE ZOLOFT! I've been on it for a little over a month and after YEARS of feeling like I wanted to die because I was so depressed, anxious, overwhelmed, etc...I felt so much better in just a few days. Side effects I experienced: dry mouth, hyperactivity for a few days (but it was good, I cleaned my house like I've never done before!), inability to orgasm after the first week (but that seems to have resolved itself now in week 5), headaches (only the first few days). The side effects are gone now and I feel wonderful. BTW, no weight gain. I actually lost 8 lbs. because I don't do the "emotional eating" thing anymore. I hope it works as well for you as it has been working for me. BTW, I am on 50 mg. of Zoloft during the day and 25 mg. of Seroquel to sleep at night (but I only take that every few days or so when it's getting late and I am still not sleepy--zoloft has improved my sleep habits so I don't need the Seroquel as much). Good luck.