Well, I've been on Wellbutrin (along w/ Zoloft, slowly tapering off of that) since Friday and I feel like I'm on speed. I talk a mile a minute and my eyes look like they are going to pop out of my head. However, I'm certainly not tired like I used to be on the Zoloft and Seroquel AND I think I'm nicer to people. Yesterday, I kept busting out laughing for no reason. And yea, this morning, my pants felt a bit looser. Am I losing my mind or is this stuff working already? Zoloft started kicking in within 3 days. My MD says I respond to medication well and I probably am feeling the effects already. I just wonder...will I settle down? I like the elated, I don't give a bleep attitude but damn, I need to slow down. Oh well. The headaches, speedy feeling and dizziness is fine by me as long as I can loose this Zoloft weight. Ugh!