Discussions that mention simvastatin

Cancer: Prostate board


Thanks for pointing this out. The follow-up study in humans may lead to results that will support my own program.

I found accounts of a study that sounds like this one, a study led by Rutgers researcher Zheng involving cancer cells in the lab and in mice. Dr. Zheng reported better cancer control from both drugs than from either alone. It was reported last April at the annual conference of the American Association for Cancer Research. Is this the same study?

I've been on both Celebrex and statin drugs to support my therapy against prostate cancer. (These were/are sort of a side show to my main program, and I don't usually mention them.) I stopped Celebrex long ago as it did not seem to make much of a difference for me, though my muscles sure appreciated it - noticeably less stiff and sore from workouts and heavy chores. I stopped mainly because my insurer was concerned about apparently low risks of serious problems and would no longer pay for it, my oncologist was not convinced the benefits were worth the risk, and neither was I. I'm still on simvastatin because of other news that it seems to cut the risk that prostate cancer will take a lethal turn; that seems particularly so if a patient has been on it for three years or more. I would be delighted if some solid trial results put a low-dose combination of these drugs back in play.

I was hoping the study you reported would involve results with human patients, but that is not the case. :( However, the accounts I read suggested that human trials would start soon. :) Often good results in mice don't pan out for most human patients, but I've got a good feeling about this particular combination. We may have to wait a few years, but it would be worth a wait to be able to add this combo to our arsenal.

Jim
Hi Csyleen,

In answer to your question, there's strongly suggestive evidence that statin drugs generally reduce the risk of advanced prostate cancer. :D (Note that they don't seem to reduce the occurrence of prostate cancer itself but instead limit the severity. Also, the drugs see to help protect against the very serious forms of the disease but don't at all guarantee good results.)

The evidence has been accumulating for quite a few years now, but I have to admit I personally was reluctant to start an additional drug - the statin - without clearcut evidence (still not there) and with a risk, admittedly low, of muscle complications. What moved me to act was the report from some high-powered researchers that statins appeared to reduce the likelihood of advanced (especially metastatic and lethal) prostate cancer. This was the 2006 paper by Drs. Elizabeth Platz, Walter Willet, Edward Giovanucci, and others. Apparently there is some benefit quite soon after starting, but research indicates that being on the statin for at least three years gives a much better level of protection. :) I started a low-dose of simvastatin (generic Zocor) on 6/7/2007, so I'm now at the 1 1/2 year point. (I wish I had started sooner, one of the few regrets in my choices in dealing with my case. :( But it's a lot better being somewhat late than never starting. :))

Another important point relates to statins and the supplement Co Q10. There is solid evidence that those of us taking statins should also make sure we are getting enough Coenzyme Q10. I was at a presentation where Dr. Charles "Snuffy" Myers mentioned this connection, saying that statin users should be on a low-dose of Co Q-10, a supplement he does not normally recommend. You can go to the same PubMed site and search for " statin AND coenzyme Q-10 " to see some of the related papers.

There has been and continues to be a lot of research on statins and prostate cancer. You can check some of it by going to [url]www.pubmed.gov[/url] (which we are allowed to mention on this board because it is a US Government website) and searching for " statin AND prostate cancer ". When you see a title of a paper that interests you, just click on the blue hyper text for the author's list, and you will get an abstract of the paper if there is one.

If you do some detailed research using PubMed, I'm sure a lot of us would be interested in what you turned up.

Take care,

Jim