I switched from Neurontin to Lyrica to Topamax. The Topamax actually has a side effect of weight loss. Not much but at least no swelling. The swelling was killing me. I take a bunch of other meds. I also have Obstructive Sleep Apnea among other things. The meds don't interact. Maybe mention to your doctor. He would know what would work together. I would wake up in the morning and not even be able to open my hands because of the swelling. All my joints hurt. I was only on Topamax a short time when my stomach problems happened so I stopped taking that and the Skelaxin because everything causes nausea. Now that I am starting to eat a little I am starting them again.