Discussions that mention spironolactone

High & Low Blood Pressure board


Hi, Max

Check out this article:

Aldosterone blockade helps heart attack patients--

[url]www.hon.ch/News/HSN/512487.html[/url]

Following the RALES trial of spironolactone for heart failure, Aldosterone elevation was for the first time considered to be a precursor of heart failure.

I wonder if elevated aldosterone might also be causing the increase in glucose seen in potential heart attack patients in the study you cited. Aldosterone is not touched by ARBs or ACE inhibitors. In the article cited above, they have decided aldosterone blockade is a good strategy for heart attack patients. I wonder why they don't seem to be considering establishing the blockade _before_ heart attack or heart failure occurs.

Hmmm.

Pam