Discussions that mention spironolactone

High & Low Blood Pressure board

Hi Huskie, :)

I am not very familiar with Candesartan. I tried two other drugs from this class (Diovan and Micardis) and could not tolerate them.
I am taking Lasix though, in addition to my two diuretics, Hctz and Spironolactone. Since the addition of Lasix about two weeks ago, there's been no change in my blood pressure. My primary reason for taking it was to help with edema. There's been no visible improvement. Under normal circumstances, it is a POTENT diuretic.

Did you know that the books say that IF the hypertension cannot be adequately controlled with thiazide diuretics, it will NOT be adequately controlled with Lasix alone. I know you are taking another antihypertensive drug as well. That might make a difference. Perhaps you'll see better results if you wait a few more days.

Some thoughts regarding these drugs:

Lasix is a potassium WASTING drug
Candesartan is a potassium RETAINING drug

Hopefully, you'll break even and your potassium levels will not fluctuate too much. It won't hurt to eat a potassium-rich diet. Have regular labs done, especially the electrolytes. You have to keep an eye on them.

The expected side effect of Lasix on most people is an increased urination. If that does not happen, and you find yourself going less often or not at all, tell your doctor. Make sure to replenish the lost fluid and sodium to avoid dehydration. Keep an eye on your blood pressure readings to avoid excessive drops in blood pressure. Our doctors are supposed to DECREASE the doses of other bp meds when they start their patients on Lasix. Mine didn't. Luckily (or unluckily, depending how you look at it :D), nothing happened.
Reduce your alcohol consumption and salt intake-keeping in mind you need SOME sodium daily,especialy while on Lasix. Just don't go overboard with either! :) Either of these could be keeping your blood pressure elevated, making it difficult to control.

I am wondering why your hypertension seems to be resisting treatment. The most frequent causes people can't get their blood pressure controlled with medication are non-compliance and not adopting the diet and other recommended lifestyle changes.

I hope this helps at least a little bit. I too have resistant hypertension and control it with five-six drugs. It took a while to figure out the best possible combinations and dosages. Several doctors seem to think my therapy is suboptimal and that there is a lot of room for improvement. (=fewer drugs in more effective dosages/combos). But it appears no one is willing to take the leap and make changes to it. ;) Oh well.

good luck,