I was just diagnosed with hypothyroidism (5'6" 120 lbs. go figure!) yesterday. I was put on synthroid. My question is, can I take it at night before going to bed? I already take Zoloft 50mg in the morning and Clonidine 0.1mg at night, both for menopause symptoms. I took my first synthroid this morning and my head feels out of whack and I have a bad headache. Is this normal and if so what can I do to clear my head? It's awful! I'm scared now to take over the counter things for headache. Thanks for any help.