Well I've been on it for 2 weeks now and there is no difference in the pain. It does nothing for the pain or stiffness. What it seemed to do was give me a mental lift simular to caffine. But only for the first week I took it. The company that makes it says it does not have any stimulants in it. The second week... it does nothing. Since i am on Synthroid, I would think this would work better on me than anyone else since Myalgistat is suppose to convert the T4 thyroid hormone to T3. Anyway, I thought I'd let you know. Go thing they give you a money back guarantee. I'll be sending oit back to get my 69 dollars back.