My docotor recommended that l take two tablets in the moring and one around 3:00 in the afternoon. Each tablet l believe is 5mg, and l took 1/4 th of a 5 mg tablet. It was almost nothing, my doctor said if you took 100 people off the street and gave them 5 mg they wouldnt feel anything. I havent been on any medication for 6 years, l was taking a very low dose of synthroid for about 1 year but got off. If the cortef made all my symptoms increase that would tell me that something isnt right with my adrenal glands, but not sure what? My doctor is at a dead end and now l dont know what to do because l cant keep living like this.