My mom has graves disease-since 1983 at age 49. Had a hysterectomy in 1987(or '88)and has had no problem since...She takes premarin and I think synthroid. She has bloodwork regularly...She can usually tell on her own if she needs to have it done sooner than scheduled--she feels "off" she says and knows she needs her med adjusted. She's very happy she had it done and has had no trouble at all--she'll be 71 in Sept. Good luck to you!!