Discussions that mention thyroxine

Dizziness / Vertigo board

I'd not heard of "white matter disease" before, but when I did a web search, I found that there is a condition called "Hashimoto's Encephalopathy" that relates Hypothyroidism with White Matter Disease.

It's apparently a condition associated with Hashimoto's antibodies and is treated concurrently by corticosteroids and thyroid meds (and sometimes anticonvulsant meds). Medscape calls it "a steroid-responsive relapsing autoimmune disorder first reported in 1966" and goes on with this clinical description:

[quote]Hashimoto's encephalitis should be considered in the clinical setting of relapsing encephalopathy. Relapsing white-matter edema, if present, is suggestive of the diagnosis. Thyroid autoantibodies are present invariably. Most patients have anti (microsomal) peroxidase antibodies (anti-TPO) and antithyroglobulin antibodies may be present. Their presence is required to make the diagnosis; but, caution is necessary, as 20% of the adult female population have detectable anti-TPO. The mainstay of therapy is corticosteroids, thyroxine, and anticonvulsants.

Medscape also mentions that there are two types of White Matter Disease:

[quote]The radiographic differential diagnosis for diffuse white-matter disease of the brain is divided into myelinoclastic disease (i.e., diseases that destroy normally formed myelin) and dysmyelinating diseases that prevent normal myelin formation.

Let us know what the spinal tap reveals. And have them test you for the various types of thyroid antibodies (including those listed above). You can also read more about thyroiditis, thyroid antibodies and supplements that may help (Selenium, Maca) in our Information Archive thread if you've not yet had a chance.