Discussions that mention toprol

High & Low Blood Pressure board

After numerous complaints being filed to the FDA regarding the side effects of the "supposed" new generic forms of TOPROL XL. Numerous testing labs have confirmed that the generic is not the same as the brand TOPROL XL. PeoplesPharmacy and ConsumerLabs have confirmed this in bioequivalence studies. Insist on the brand TOPROL XL from Astra Zeneca. People have complained of dramatic increases in heart rate and blood pressure, dizzines, hives and headaches etc. while on the generic substitute. 3 Pharmaceutical companies were cited for inferior pills. This confirms the numerous reports of side effects popping up over the past year....
The pharmacies and also many doctors will tell us that the generic and brand are the same thing. When tested by various independent labs, apparently this is not always the case. The testing found multiple inactive ingredients not found in TOPROL XL. This can have serious side effects for many who are sensitive to these ingredients. Also, a pills content may be 7% over or 7% under the stated content. The FDA requires that any approved drug be effective within a 20% range of the original patented or brand name drug. This means that the effectiveness may be 20% greater or 20% less effective than the brand name so that two generic drugs could contain as much as a 40% difference from each other. Numerous alerts were posted for Tetracycline, not having the proper ingredients. This means infections can get worse and continue to spread. The generic drug Tegretol was causing seizures. Until recently over 80 % of drug ingredients came from plants throughout Europe. According to the New York Times, generics are being made much more cheaply with ingredients coming from Korea, India and China. According to the National Association of Pharmaceutical Manufacturers only a small handfull of these plants meet FDA standards.

I checked the price of generic ATENOLOL on my Pharmacy mail order site, The cost for 90 pills of the generic was $4.17 and the cost for the brand for ATENOLOL (TENORMIN) 90 pills was $127.60. If my copay is 25.00 which pill will the pharmacy dispense? You guessed right, the cheapest pill he can give me. That's why pharmacies insist that the generics are the same as brand.
As I see it, the danger with these generic substitutions (which the pharmacies have the legal right to substitute without notifying the doctor or the patient) is that heart and blood pressure medications have to be manufactured to precise standards and dosing. This is the main reason that new brand drugs and manufacturing standards are scrutinized by the FDA for the proper placebo studies and the millions of dollars in costs to the pharmaceutical companies to get these drugs properly tested and approved. The generic drugs "do not" have to perform these studies to sell and market their pills. The FDA is very happy about all this because it keeps pill prices lower and more affordable. Besides, you can't prove that the seizures, strokes and spread of infections are due to the pills. The sad thing is that many of us are required to take these pills for life. Which reminds me, I need to take my medicine.....

P.S. I did some heavy research on this. Unfortunately, most insurance plans will only cover generic pills. If you are having problems with your new generic pills, with side effects not experienced before, tell your doctor. When he fills your new prescription you can have him specify "DAW" (Dispense As Written) which requires the pharmacy to prescribe only the brand drug. The good news is that many brand drugs are much cheaper and affordable because of the generic competition. The generic TOPROL XL is about $50.00 and the brand is about $75.00 (for most doses) Tell your doctor to prescribe a higher dosage and you can split it in half.
I feel bad for my parents who are old and on a pension. Their insurer (EPIC) will only pay for generic drugs. Both my parents take TOPROL among other drugs. They pay a $20.00 COPAY for each generic drug they purchase. If they opt for the brand name they will have to pay almost entirely for the prescription. Like most senior citizens, when you are on a fixed income, it is very hard to pay full price for pills. It's bad enough that we need to take certain pills, but to be told by our insurer and pharmacy that they will not pay for any other brand pills and without our knowledge be switched to the cheapest untested pill is terrible. The complaints in the past were always directed at the big drug companies who charge higher prices for new brand name drugs. At least most of time these pills were tested and they worked. The generic manufacturers on the other hand (Of course, I do not mean all generic manufacturers) are producing the cheapest mixture of junk fillers, and the most inferior products with almost no quality assurance, and the public is forced to purchase them, and continue on them indefinitely. The worst part of all this is that these pills do not always work to lower blood pressure or cause some other unknown horrid side effects. A pharmacy or drug store chain now has the option to purchase drugs from a wide selection of Generic manufacturers. (Many companies pop up over-night) Most pharmacies will purchase the largest bulk of pills at the cheapest price. If the ACME pharmaceutical company with offices in Osh-Kosh wants to sell 65,000 untested/expired pills (manufactured in the Amazon) for dirt cheap, they will find a huge success with most of the FDA approved drug chains. They can then pass on these great savings to the public who have a valid prescription which entitles us to improve our health.

P.S. The concept of generic pills was created to try and keep prices down and create more competitition for the big brand name drugs which are very over priced. We now have about 25 companies from all over the world manufacturing the same pill. Some pills are as low as $3.00 for 90 pills (ex. ATENOLOL) The pharmacies are paying bargain basement prices with our health. I think the Generic concept would have been fine if proper standards
were maintained. I am a firm believer that to a large degree "You Get What You Pay For".
I had the exact same issue with the generic version of Toprol 25mg. Had my doc write it as no substitutions. I'm on only 25mg a day (trust me lots more meds than that to control BP) but I did notice the difference.
Apparently the best generic for TOPROL XL is from PAR pharmaceuticals according to CONSUMERLABS and PEOPLES PHARMACY. PAR pharmaceuticals
is a kind of distributor for ASTRA ZENECA the brand TOPROL XL. The worst are from EON LABS (a divison of SANDOZ) and ETHEX (a division of KV Pharmaceutical). At least we have 1 acceptable generic to choose from.
Another generic which is under scrutiny is a pill called WELLBUTRIN XL. If you take any of these generics, take at your own risk.
Hi Ace - This news is really unsettling, to say the least! It shouldn't be legal to change the brand name drug in any way! Why can't they just give the formula to the company making the generic version? How do we even know that the 'extras' they put into the generic drugs are safe? Is the FDA doing anything about the generic versions of Toprol - or are they just 'looking into it'?? Now I'm wondering if Bystolic is different fromNebivolol?
Bystolic is not working at all for my systolic pressure! According to what I've read about Nebivolol, it lowers both systolic and diastolic; but it has even managed to raise my diastolic pressure a little. Is Nebivolol exactly the same as Bystolic? mabent :(
I can tell you that most generics are safe, effective, and cost way less than the brand names! I take metoprolol for my blood pressure ( I used to take Toprol), and I take generic birth control pills! My blood pressure has been perfect with the generic and I have had no problems with my birth control! I believe some people have a sensitive body chemistry and therefore may have problems with the inactive "fillers" in some medications. But, as far as being equivalent in the active ingredients, the FDA is very stringent about that! I am glad for generics because they really do save money and for most people they work just fine!
Hi Kellis,

I agree, but their are exceptions with many generics being sold. The active ingredient needs to be within 20 - 40% of the active brand drug. In many cases they are not. The 2 main generic pills which are being cited at present are WELLBUTRIN XL and TOPROL XL. The way they disolve is not acceptable for an Extended Release tablet. This can be very dangerous. I've taken BISOPROLOL (generic) and it did not equal the heart rate control of ZEBETA the brand pill. While shopping one afternoon my heart was constantly skipping beats. PAC's and PVC's were almost non-stop at times. ZEBETA showed a dramatic difference in the frequency of these PAC's. I have also taken METOPROLOL some years back (the brand name was LOPRESSOR). Either METOPROLOL or LOPRESSOR appeared to be tolerable. I never noticed a difference. At one time the generic drugs made up only a small percentage of the prescribed drug market. Most of the time the brand drug companies worked together with a generic company to manufacture the same pill. In fact, certain generic companies are owned by the larger brand drug companies. Today the generic market can have up to 10 different companies manufacturing a particular drug. The bottom line is: Some comapnies are definitely better than others with their manufacturing standards. The dilemma is: Which companies are better or worse? It is almost impossible for the FDA to evaluate all the pills which are being mass produced by 10 or more different companies, and test these batches on an almost daily basis. The FDA picks 3 or more pills at random from various stores and tests them for active ingredients within a certain threshold. Does this assure the public that the pill is safe and effective?? The good news is that many brand name drugs are dropping their prices and making the brand drug more affordable. When LIPITOR becomes generic in a couple of years, About 20 or more generic companies will want to acquire market share of this blockbuster drug. If LIPITOR side effects are horrible now, wait till the generic pills become available. It will probably stop most of us dead in our tracks.
[QUOTE=ACE28;3724312]Apparently the best generic for TOPROL XL is from PAR pharmaceuticals according to CONSUMERLABS and PEOPLES PHARMACY. PAR pharmaceuticals
is a kind of distributor for ASTRA ZENECA the brand TOPROL XL. The worst are from EON LABS (a divison of SANDOZ) and ETHEX (a division of KV Pharmaceutical). At least we have 1 acceptable generic to choose from.
Another generic which is under scrutiny is a pill called WELLBUTRIN XL. If you take any of these generics, take at your own risk.

Good info Ace. Awhile back my Toprol XL 100 mg was switched to a generic and I didn't think much of it because I didn't notice any difference. After reading this post I went to look at my bottle and it says PAR PHARM. Thanks to your info I will make sure all my future re-fills are from PAR. It is very affordable for me, 90 day supply for 10.00