Discussions that mention toprol

High & Low Blood Pressure board


Hello all, stumbled on your forum research Bystolic. Had high BP for 10 years been on Toprol and lisinopril/hctz. Drugs weren't working well and was tired of Toprol after 5 years (bouts of depression and exhaustion). Recently started having PVCs; had them for a about a month (freaked me out); cardiologist switched me to Bystolic 10mg after wearing the holter monitor plus linsinopril no HCTZ one week ago. All I can say is WOW! BP went from average of 145/90 to 111/67. PVCs have completely stopped. Now the side effects (and wanted to know if anyone else has heard of this): weird tingling on right side epecially in leg/foot almost like it is falling asleep (pins and needles) ; low pulse, I run about 75-80 resting now running about 57-61. The tingling is what is worrying me. No other real side effects. The best way to describe how I feel is chilled out. Really too chilled out ( I am a type A guy) as if my drive is lessened. I don't feel exhausted just unmotivated. I am thinking about splitting the 10mg pill and going down to 5mg/day and see what happens. Any suggestions from the group? I love the low BP numbers and the calmer feeling but wonder if much of it could be achieved with 5mg instead of 10mg. If the tingling keeps up, I will have to switch off bystolic b/c it drives one a little crazy. Any input is appreciated.

PS. ACE28 after reading your posts I am beginning to wonder if I got a bad batch of Toprol generic. My horrible run of PVC that started all of this, started a few weeks after I got the new Toprol generic filled. I had never had PVCs like this before. And, they stopped after I started Bystolic. Something to think about.
Hi Drdaddy,

Does the Dr indicate that you are a doctor?? If you are, then welcome to the board. Doctors could learn alot from patients (unfortunately).
After experimenting with several beta blockers, I can say that all beta blockers slow your system down a little, and take the edge off. this is part of what they are meant to do. Some more than others. I believe some of the side effects you are experiencing with TOPROL is due to the generic formulation you were switched to called METOPROLOL XL. You were fine almost 5 years on TOPROL XL (brand) and now your getting PVC's with the new generic. I have never tried the generic, but the horror stories I've been reading all over the web and the ConsumerLab and PeoplesPharmacy articles are enough to convince me that something is wrong with the generics for this pill. Surprisingly, the TOPROL brand is not much more money than the generic. I think you should definitely ask for the TOPROL brand name. As far as BYSTOLIC is concerned, as I mentioned in other posts it provides excellent heart rate control and almost completely eliminates PAC'S, PVC's etc.
BYSTOLIC was excellent in regard to certain gastric issues (stomach pain, constipation etc.) I'm convinced it helped target my bowel inflammation and cured some negative stomach side effects I had while taking BENICAR and DIOVAN in the past. My blood pressure control was pretty good on 5 mg a day (approx. 135/85). The problems I had with BYSTOLIC in the beginning were very sharp needle like pains in my knees, especially when quickly standing. At times I felt crippled when using the stairs at work. (which I always do) The knee pain later improved, but I then began to experience extreme fatigue while at work. If I closed my eyes I would drift off almost to a deep sleep. This was fine at night, but in the day, I have a job and need to work. I also experienced pins and needles alot when laying on my side. My metabolic profile had also changed for the worse (after approx 4 months) my total cholesterol increased approx 40 points, my HDL dropped by about 5 points and my glucose went from about < 105 to >= 126. (I am not diabetic) My doctor was surprised at these numbers (so was I) My weight had also increased by approx 8 - 10 lbs) so possibly the weight gain affected my numbers. The problem is, certain beta blockers increase weight more than others. This pill is not "supposed" to have these effects. Another problem was in the sex department, BYSTOLIC definitely prevented morning erections, (that is clear, especially when I could almost set my clock to this natural occurrence) and this will surely relflect sexual function when the moment is right. TOPROL definitely has never caused this problem for me, BISOPROLOL has a kind of VIAGRA effect. (BISOPROLOL studies indicate that testosterone levels increase or are not affected, and firmness of erections greatly improve, especially for men on other HBP meds. whose sex lives and libido were almost shut down) BISOPROLOL caused a great improvement. I tend to believe this. NEBIVOLOL/BYSTOLIC was suppose to also improve or not effect sexual function because of the NITRIC OXIDE theory. After more than four months, my sexual parameters did not seem in the least improved. BYSTOLIC appears to be a little less than neutral compared to othe beta blockers (Kind of like luke warm).It's possible that maybe giving the pill more time, these effects may have improved. If I was single this wouldn't matter as much. I am married and my wife would like some passion once in awhile. The only other pills which did not appear to effect sexual function was DIOVAN. All the others COZAAR, ALTACE, BENICAR and Ace inhibitors have a negative effect, especially on libido. (For me anyway - but keep in mind, Everyone reacts differently to meds.) This brings us to another thing you mentioned, the Ace Inhibitor LISINOPRIL. According to many, this pill is slightly better than RAMIPRIL (and thats not saying much). When I took the Ace Inhibitor ALTACE/RAMIPRIL I had numerous PVC's, dry mouth, cough etc. Unfortunately, my doctor dropped the TOPROL and switched me from ALTACE to DIOVAN. Which was a little better, but I still had PVC's. The PVC's improved after while. Of Note: According to WEBMD and other books published, only ISRADIPINE (a calcium blocker), DIOVAN and a couple of beta blockers (BETAXOLOL) do not promote sexual dysfunction. Every other approved medication has been known to effect sexual parameters and qualty of life. This is why 65% of men drop their blood pressure meds.

In conclusion, keep in mind that also LISINOPRIL is also sold in generic form, so now you are taking 2 generic medications. If all else is well with BYSTOLIC, it is definitely a better a choice than generic TOPROL and LISINOPRIL. TOPROL- XL is another story, You were OK for 5 years on TOPROL. In regard to depression, this can also be caused by LISINOPRIL and all the other Ace Inhibitors. I suffered depression while I was taking BENICAR. The HCTZ supposed to work best with all beta blockers. The Ace Inhibitors (LISINOPRIL) are not combined with beta blockers too often. My doctor took me off PERINDOPRIL/ALTACE another Ace Inhibitor when he prescribed 5 mg of BYSTOLIC. He said that 5 mg is the approved starting dose. You can always work upward with medication. I believe this is a good strategy. BYSTOLIC appears to provide many of the benefits of Ace INHIBITORS including the Angiotensin effects and Vasodilation. This can be called the All in One pill.

P.S. drDaddy, I hope this information helped
The TOPROL XL pills are scored, this makes them very convenient to split very evenly. BYSTOLIC tablets are triangular in shape and are not scored, this is rather inconvenient. At least BYSTOLIC is not like ALTACE or other medications which are in a capsule form. I think Ace Inhibitor's are often prescribed because they offer great kidney protection, they keep glucose levels in check and research studies indicate that they prevent heart attacks and strokes. Not many HBP medications including diabetic medications provide this level of protection. I guess the most important question is: How high is the blood pressure? Do you have a kidney issue? , Are you diabetic? , Does heart disease run in the family? . These can be reasons why a doctor may prescribe an Ace Inhibitor. My cousin recently had extremely high blood pressure readings which affected his kidneys. He is currently on 5 different medications. All the different HBP meds. work by different mechanisms. Ex.Calcium Blockers, Diuretics, Alpha Blockers etc.. With hypertension, doctors don't know which pill will be best for which person. So therefore, they will prescribe 2 or more pill combinations. I believe that it is best to start with 1 pill in a low dosage and slowly work upward. Luckily, my doctor also believes in this approach. Many medical experts believe that a diuretic is the most proven and effective pill to control blood pressure. I think it was the ALLHAT study which compared all the current HBP medications and found that ALPHA BLOCKERS were the worst pills (study participants had to be switched to another medication because the death rate was so high) Calcium blockers were the next worst, and Ace Inhibitors and Beta blockers were neutral. This was a very large trial with thousands of participants lasting for more than 5 years. Diuretics help to flush out fluid and salts and keep the weight in check. This lowers blood pressure in most people. The maintenance cost is also very cheap. They also have their laundry list of side effects. Keep in mind that the large pharmaceutical companies in this country are making billions in profits by promoting these other newer classes of drugs. They are not going to sit back and watch a diuretic which is a 40 + year old pill which costs about 10 cents each replace this lucrative HBP market of drugs. Doctors are then forced or offered incentives to push these newer pills on us by the pharm.representaives. New medical students are trained in colleges to push these rather ineffective pills on us. Huge grants and contributions are provided to medical schools by Drug companies. I wonder why? With high blood pressure we have to be our own doctors. Try and avoid stress, cut out salt, watch the weight etc. I am also about 6 foot and weigh about 225. It does not show because I have a large frame. I can also afford to lose about about 15 - 20 lbs. You are much younger though. I am 50 years young. I think it best to make an appointment and speak to your doctor. Tell him you are taking half the pill because of possible side effects and that you would like to try controlling your blood pressure with only one pill. If blood pressure is not controlled you can increase your doasge. If your doctor is stubborn or gets annoyed or is not flexible and understanding, I think it's time to consider a new doctor. Most doctors will try and work with you. We are paying him so we can get well and feel comfortable with the medication choices.

P.S. I know what you mean about the stress levels. I am working at a new job for approx. 2 years and sometimes I feel incredible amounts of pressure to meet deadlines and schedules etc..This is one of the main reasons I am currently taking a beta blocker and feel much better and in control. I've also had bouts of PAC's and PVC's for years, likewise I had echo cardiograms, holter monitors etc. Apparently, they are nothing of significance. A beta blocker also appears to be the perfect medication to keep the heart in check.
I am a 47 year old male, in good health. I started taking Metoprolol about 3 years ago for rapid heartbeat from anxiety and also moderate high blood pressure, in combination with Lotrel. I began to notice that the Metoprolol had some unpleasant side effects, particularly vivid dreams that would prevent me from sleeping soundly. So I mentioned it to my cardiologist, who suggested Bystolic. He said it was new and didn't have the side effects of other beta blockers. So he switched me to Bystolic 5 mg, once daily. For the first couple of weeks, it was OK. Then I started having the same side effects plus some new ones. My vivid dreaming has become more intense, and I have become intermittently forgetful, particularly with peoples' names. My cardiologist and my GP deny that the side effects are related to the medication, but I know they are. I told my cardiologist that I want to get off the beta blockers altogether. I can't stand the side effects any longer. He said I could stop taking the Bystolic, as the Lotrel should control my blood pressure. My cardiologist and GP both insist that I can just stop the Bystolic cold turkey, but after 3 years of being on a beta blocker, I plan on transitioning off over the course of at least a month. The beta blocker served its purpose when my anxiety was real bad, but I've had it with the medication and with the doctors who push them on you and treat you like you're crazy if you don't like them.
Hi Drdaddy,

I'm glad BYSTOLIC is still working for you. I'm very familar with PAC's and PVC's. About 7 years ago, I was getting them constantly and it appeared many things would make them worse. If I went outside on a very cold day or a sudden change of temperature, after eating, not sleeping well, after an extra beer etc... I had all the tests done including a holter monitor, cardiogram and echo cardiogram. My doctor clearly saw them on the cardiograms. He said that it's an extra atrial beat and nothing of clinical significance. He's convinced that something is definitely triggering these. It could be stress, anxiety, worry, caffeine or even being too overly conscious about the heart beat. I had these constant PVC's for approx 4 months. Metoprolol was prescribed which made them feel worse.
I would feel several mild normal beats, than one extra hard skipped beat. I was than switched to TOPROL XL and Altace, and I still was getting PAC's. Strangely, after about 4 months of these erratic heart beats, One day at work I noticed the PVC's were almost completely gone. Just as quick as they came, one day they were gone. I still get them occasionally but in retrospect, I have to agree with my doctor beacuse at that time I had started a new job about 6 months earlier. I was also in the process of purchasing a new home. Sometimes these transitions can have a rather uneasy effect (though we don't equate cause and effect). In the medical world why PAC'S/PVC's occur is still not completely understood but they are nothing of clinical significance. These PAC's can affect both your personal and social life (if you let them). When you get these PVC's you feel something is definitely wrong. When a doctor assures you that you need not worry and you are not going to die, you should feel great. In time it appears the fear of them will die. I think about my parents and grandparents who had to live in the worst of times, through the depression, the horrors of war, and earlier unemployment and poverty. They survived because they had to survive and not let hardships get the best of them.

P.S. I'm back on BYSTOLIC again. TOPROL appears to have good blood pressure control, but a more negative effect on my blood and lipid panel. Last month my cholesterol was higher and my CRP which is alway normal jumped by 4 points. With BYSTOLIC my CRP was <= 1. This tells me that BYSTOLIC definitely targets inflammation better and this also explains why my stomach (mild colitis) improved while on BYSTOLIC. So for now BYSTOLIC is the better choice, unless I notice an extra eye or belly button or something out of the norm.
[QUOTE=ACE28;3718688]Hi Drdaddy,

Does the Dr indicate that you are a doctor?? If you are, then welcome to the board. Doctors could learn alot from patients (unfortunately).
After experimenting with several beta blockers, I can say that all beta blockers slow your system down a little, and take the edge off. this is part of what they are meant to do. Some more than others. I believe some of the side effects you are experiencing with TOPROL is due to the generic formulation you were switched to called METOPROLOL XL. You were fine almost 5 years on TOPROL XL (brand) and now your getting PVC's with the new generic. I have never tried the generic, but the horror stories I've been reading all over the web and the ConsumerLab and PeoplesPharmacy articles are enough to convince me that something is wrong with the generics for this pill. Surprisingly, the TOPROL brand is not much more money than the generic. I think you should definitely ask for the TOPROL brand name. As far as BYSTOLIC is concerned, as I mentioned in other posts it provides excellent heart rate control and almost completely eliminates PAC'S, PVC's etc.
BYSTOLIC was excellent in regard to certain gastric issues (stomach pain, constipation etc.) I'm convinced it helped target my bowel inflammation and cured some negative stomach side effects I had while taking BENICAR and DIOVAN in the past. My blood pressure control was pretty good on 5 mg a day (approx. 135/85). The problems I had with BYSTOLIC in the beginning were very sharp needle like pains in my knees, especially when quickly standing. At times I felt crippled when using the stairs at work. (which I always do) The knee pain later improved, but I then began to experience extreme fatigue while at work. If I closed my eyes I would drift off almost to a deep sleep. This was fine at night, but in the day, I have a job and need to work. I also experienced pins and needles alot when laying on my side. My metabolic profile had also changed for the worse (after approx 4 months) my total cholesterol increased approx 40 points, my HDL dropped by about 5 points and my glucose went from about < 105 to >= 126. (I am not diabetic) My doctor was surprised at these numbers (so was I) My weight had also increased by approx 8 - 10 lbs) so possibly the weight gain affected my numbers. The problem is, certain beta blockers increase weight more than others. This pill is not "supposed" to have these effects. Another problem was in the sex department, BYSTOLIC definitely prevented morning erections, (that is clear, especially when I could almost set my clock to this natural occurrence) and this will surely relflect sexual function when the moment is right. TOPROL definitely has never caused this problem for me, BISOPROLOL has a kind of VIAGRA effect. (BISOPROLOL studies indicate that testosterone levels increase or are not affected, and firmness of erections greatly improve, especially for men on other HBP meds. whose sex lives and libido were almost shut down) BISOPROLOL caused a great improvement. I tend to believe this. NEBIVOLOL/BYSTOLIC was suppose to also improve or not effect sexual function because of the NITRIC OXIDE theory. After more than four months, my sexual parameters did not seem in the least improved. BYSTOLIC appears to be a little less than neutral compared to othe beta blockers (Kind of like luke warm).It's possible that maybe giving the pill more time, these effects may have improved. If I was single this wouldn't matter as much. I am married and my wife would like some passion once in awhile. The only other pills which did not appear to effect sexual function was DIOVAN. All the others COZAAR, ALTACE, BENICAR and Ace inhibitors have a negative effect, especially on libido. (For me anyway - but keep in mind, Everyone reacts differently to meds.) This brings us to another thing you mentioned, the Ace Inhibitor LISINOPRIL. According to many, this pill is slightly better than RAMIPRIL (and thats not saying much). When I took the Ace Inhibitor ALTACE/RAMIPRIL I had numerous PVC's, dry mouth, cough etc. Unfortunately, my doctor dropped the TOPROL and switched me from ALTACE to DIOVAN. Which was a little better, but I still had PVC's. The PVC's improved after while. Of Note: According to WEBMD and other books published, only ISRADIPINE (a calcium blocker), DIOVAN and a couple of beta blockers (BETAXOLOL) do not promote sexual dysfunction. Every other approved medication has been known to effect sexual parameters and qualty of life. This is why 65% of men drop their blood pressure meds.

In conclusion, keep in mind that also LISINOPRIL is also sold in generic form, so now you are taking 2 generic medications. If all else is well with BYSTOLIC, it is definitely a better a choice than generic TOPROL and LISINOPRIL. TOPROL- XL is another story, You were OK for 5 years on TOPROL. In regard to depression, this can also be caused by LISINOPRIL and all the other Ace Inhibitors. I suffered depression while I was taking BENICAR. The HCTZ supposed to work best with all beta blockers. The Ace Inhibitors (LISINOPRIL) are not combined with beta blockers too often. My doctor took me off PERINDOPRIL/ALTACE another Ace Inhibitor when he prescribed 5 mg of BYSTOLIC. He said that 5 mg is the approved starting dose. You can always work upward with medication. I believe this is a good strategy. BYSTOLIC appears to provide many of the benefits of Ace INHIBITORS including the Angiotensin effects and Vasodilation. This can be called the All in One pill.

P.S. drDaddy, I hope this information helped
wait a minute, I'm confused. I thought you are on Bystolic and lilked it? Did I miss something here?
[QUOTE=jamie007;4729732]wait a minute, I'm confused. I thought you are on Bystolic and lilked it? Did I miss something here?

Jaimie - Keep in mind, this thread goes back to 2008. This is just about when Bystolic was approved in the U.S As I mentioned, I switched several medications since then, but I always seem to return to Bystolic. I also mentioned that glucose and cholesterol were slightly increased in the beginning and some fatigue and joint pain (like many medications) can occur in the early months. Many other medications appeared to be worse on my digestive track, Bystolic was not. Other medications started off OK, and then appeared to get worse with time, Bystolic seems to be the opposite (for me anyway). Side effects started early then improved, until I adjusted. Then my cholesterol dropped to normal, Glucose lowered, CRP (inflammation) dropped to 0.16 (which is excellent) and all my other blood levels are perfectly normal. After another try with Bystolic for several months, sexual function and slight weight gain returned to normal again. Other medications worsened all these areas after a some months. I understand your confusion, my doctor tried me on different medicaitions and beta blockers at that time. He also prefers Toprol XL to almost any other medication. Perhaps the switching also added to more side effects and confusion. I also try to stay at 5 mg. a day or less. At higher doses I'm sure side effects will start again.
[QUOTE=ACE28;4729793]Jaimie - Keep in mind, this thread goes back to 2008. This is just about when Bystolic was approved in the U.S As I mentioned, I switched several medications since then, but I always seem to return to Bystolic. I also mentioned that glucose and cholesterol were slightly increased in the beginning and some fatigue and joint pain (like many medications) can occur in the early months. Many other medications appeared to be worse on my digestive track, Bystolic was not. Other medications started off OK, and then appeared to get worse with time, Bystolic seems to be the opposite (for me anyway). Side effects started early then improved, until I adjusted. Then my cholesterol dropped to normal, Glucose lowered, CRP (inflammation) dropped to 0.16 (which is excellent) and all my other blood levels are perfectly normal. After another try with Bystolic for several months, sexual function and slight weight gain returned to normal again. Other medications worsened all these areas after a some months. I understand your confusion, my doctor tried me on different medicaitions and beta blockers at that time. He also prefers Toprol XL to almost any other medication. Perhaps the switching also added to more side effects and confusion. I also try to stay at 5 mg. a day or less. At higher doses I'm sure side effects will start again.
Thank you ACe for clarifying all that. You know I think to this day that between the propranolol and Metoprolol that that caused me to gain a good 30 pounds and get the prediabetes, or at least it caused the weight gain thus causing the prediabetes. I am on my way down with all of that though and am so glad to be off Metorpolol though through all of this i've actually considered going back to old famililar but it gives me trouble at 25 mgs which is what i need for bp. I've felt so spacey on it and too when I take inderal and the dose wears off i feel like i've come down from a high but i didnt feel high if that makes sense. i guess i will have to wait till friday to start my minute dose because i want my husband home when i take it and he comes home to late in the evening and i take thyroid pill at ten at night. I'm going to take this in the evening about 6 or 7 hopefully on a regular basis because I get early monring high bp and anxiety which triggers the high blood pressure.
Bystolic will reverse the glucose problem and not be such a problem with weight gain. Some have lost weight with Bystolic. The side effects I most often hear from different boards is some shortness of breath in the beginning (This is usually mild) and some complain about hair loss. Is this definitely related to the drug?? Who really knows. Most beta blockers have a tendency to cause a slight glucose increase and some weight gain. Bystolic is more neutral in this regard. If Bystolic is not right for you, there are other beta blockers. Some do great on Atenolol or Nadolol. The more lipophilic beta blockers such as Metoprolol, Propranol, Betaxolol and even Bystolic are supposed to be the best for anxiety related issues. Betaxolol and Propranol have actually been researched in the areas of anxiety and psychiatry.
[QUOTE=jamie007;4729826]Thank you ACe for clarifying all that. You know I think to this day that between the propranolol and Metoprolol that that caused me to gain a good 30 pounds and get the prediabetes, or at least it caused the weight gain thus causing the prediabetes. I am on my way down with all of that though and am so glad to be off Metorpolol though through all of this i've actually considered going back to old famililar but it gives me trouble at 25 mgs which is what i need for bp. I've felt so spacey on it and too when I take inderal and the dose wears off i feel like i've come down from a high but i didnt feel high if that makes sense. i guess i will have to wait till friday to start my minute dose because i want my husband home when i take it and he comes home to late in the evening and i take thyroid pill at ten at night. I'm going to take this in the evening about 6 or 7 hopefully on a regular basis because I get early monring high bp and anxiety which triggers the high blood pressure.

Jamie - FYI - You mentioned Inderal wears off. Their is a new formula called Inderal LA which is an extended release formula which does not wear off and lasts 24 hours. Maybe you can ask your doctor to prescribe this..
[QUOTE=ACE28;4730882]Jamie - FYI - You mentioned Inderal wears off. Their is a new formula called Inderal LA which is an extended release formula which does not wear off and lasts 24 hours. Maybe you can ask your doctor to prescribe this..
Thank you ACE for that info. I've been on Inderal LA before I went over to Metoprolol. The dose is too high and I believe between the Inderal LA and the Metoprolol is what caused this weight gain thus the prediabetes. I so wish they would make it a lower dose like 10 or 20 mgs in the LA then maybe that would be perfect. I was reading about the shortness of breath and I get that with inderal even on 10 to 20 mgs. Not all the time but some times i do get it and it seems to correlate with taking inderal but also I've noticed it when I take valium too and I only take 2.5 mgs of valium at a time and not very often. Thanks so much for you help!