Discussions that mention toprol

High & Low Blood Pressure board

Hi flowergirl,

As I mentioned in a previous post, my glucose levels were slightly elevated
when I had my last blood test. I definitely think that certain medications can contribute to Glucose tolerance. The medication I was taking at the time was BYSTOLIC. I've taken TOPROL in the past and did not experience any changes with my glucose tolerance. (Though I was a little younger at the time) TOPROL did lower my HDL cholesterol and raised my cholesterol.
The beta blockers which are not suppose to effect glucose metabolism are: COREG, LABETAOLOL and BYSTOLIC. As I mentioned, the jury is still out for BYSTOLIC (as far as my numbers are concerned). Perhaps my numbers were a fluke and possibly due to an increase in weight, (which is definitely beta blocker related). The HBP medications which are known to improve glucose tolerance are: MICARDIS (definitely), BENICAR, DIOVAN, COZAAR, ALTACE, ENALAPRIL and Perindpril (Probably). I am currently taking a beta-blocker known as KERLONE (Betaxolol). It will be interesting to see my glucose numbers at my next check-up. As far as tolerabilty, KERLONE is excellent (possibly the best beta blocker, though not at all popular) This beta blocker is also marketed as Eye drops (for gluacoma). It is manufactured by SANOFI pharm. (France). Joint pains and fatigue are much less then some of the other beta blockers I've taken. Quality of life is not affected either. What needs to be seen now is my blood test results, blood pressure control and heart rate control. (BYSTOLIC is superb for heart rate control). KERLONE is almost identical to TOPROL but without certain side effects such as sweating and certain vague pains. (We need to choose among the worse of the evil side effects we can live with)

P.S. The supplement "Chromium Picolinate" available cheaply at most drug stores and food market chains, has been proven in many scientific studies and respected medical journals to greatly improve glucose tolerance. An added bonus is a 10 - 15% increase in HDL cholesterol (especially when taken with NIACIN). Another popular Chromium blend is called Chromium GTF, which I believe is bound to NIACIN. My mom's aunt was told by her doctor to take a Chromium supplement about 30 years ago, (I would sometimes purchase them for her) She had a heart condition among some other conditions when she was younger. To make a long story short, she lived till 98 years old, and swore by this vitamin...

The drug KERLONE is known as BETAXOLOL, which is a highly selective beta1 blocker, with no ISA. Closely identical to BISOPROLOL and moderately lipophilic similar to METOPROLOL/TOPROL. It also has some CALCIUM Antagonism, similar to TIMOLOL, and is a mild vasodilator (according to some research studies). My doctor was not to keen on prescribing this beta blocker.
Mainly due to the fact, that it is not even remotely popular in this country. He later stated, that he likes the drugs properties which include all the METOPROLOL similarities, most important that it is a beta1 blocker. I learned of this drug on WEB-MD which quoted some respected authors as stating that this is one of the only drugs in the beta blocker class with almost no sexual side effects or impairments on quality of life. The other pill was ISRADIPINE a calcium blocker and DIOVAN an ARB. They stated that almost every other medication class has been known to cause sexual side effects (some happening over time). Keep in mind, that this still only relates to a small (reported) population. Also, many persons never report these side effects and most drugs are rarely tested for these side effects. Quality of life is the primary reason (the article states) that most hypertensive patients ditch their medicine and refuse any other medicines. The estimates are that more than 60% of men discontinue their medications, and an even greater % of both men and women have poorly controlled blood pressure (even those taking medication). I think the best move is to always try and work with your doctor, and if one medicine doesn't agree with you, there are many others.
I think alot has to do with $$$ for research studies. METOPROLOL/TOPROL has been proven in over 90% of research studies to prevent MI's, improve heart function, improve Ejection fraction, prevent sudden death, improve heart failure etc. It appears to be the model beta blocker which all future beta blockers would like to copy. PROPRANOL was the first beta blocker, to show proof of it's benefits. Are all beta blockers similar?? Most beta blockers appear to provide similar benefits such as TIMOLOL, ACEBUTOLOL, CARVEDILOL and BETAXOLOL. Though the studies conducted on these beta blockers were much smaller (except for CARVEDILOL). CARVEDILOL is always trying to compare itself with METOPROLOL in large studies. CARVEDILOL boasts that the benefits of their beta blocker are either equal or greater than METOPROLOL. Keep in mind, these CARVEDILOL studies are funded mostly by the CARVEDILOL folks. Also, they seem to use METOPROLOL instead of TOPROL XL which has shown dramatic benefits in the heart failure studies. ATENOLOL appears to be the most popular prescribed medication in Europe and elsewhere. All new BP pills on the market seem to compare their new pill to ATENOLOL and always try to boast better results. I think they choose ATENOLOL over METOPROLOL because ATENOLOL can't boast the dramatic mortality benefits. A beta blocker called BUCINDOLOL (pretty popular in Europe at one time) showed almost no benefit at all in research studies. Results were = to a placebo pill.

P.S. I think it is a doctor's job to prescribe the pill which can provide the greatest level of proven benefit. Side effects are secondary. On a personal note, I have never had any quality of life problem's with TOPROL if the dose is kept small enough. When the dosage gets > than 100 mg trouble starts. Luckily, most of us can tolerate these lower doses, and see good blood pressure results.