I do think that Renova is usually given for wrinkles,hyperpigmentation... and Retin-A for acne. Both medications do have Tretinoin in them, so I am not sure why one is given for acne and the other for wrinkles. I think the Renova is a cream? Maybe this one is given for people with more dry skin and Retin-a for those with oily skin (usually acne prone). This is just a wild guess. I wonder if Retin-a is in a gel usually? Do you have acne prone skin that tends to also be dry? I'm currently using Green cream which has retinol, but plan on getting some tretinoin when I see my derm. I love this stuff. It is really helping my skin.