Erica...the study you are refering to speculates that the effect of cimetidine
is due to its possible antiandrogen effects, but more recent research (see my research reply on page 8 of this thread, and sweetjades research on page 7..)...suggests that the effect of H2 antagonists is due to their ability to modulate the immune system
Even in the study that you found, it mentions that hormone levels aren't actually altered, so perhaps they are so surprised by the effect of the cimetidine
on the skin that they say that it must have some sort of androgen altering propertiy...? Because hormone imbalance is the ONLY acceptable current acne-genesis theory?..(this is common in the history of science..experimentors fitting in erronous experimental results with existing paradigms)
Either way, the science is building up, thanks to yourself, sweetjade, freerider and redshoes, the theory now has a tremendous amount of evidence, i am going to re-read all of the important posts in this thread, and summarize them and then re-post it because there is now so much infomation scattered around this thread, it needs to be brought together... i truely believe this could be a paradigm shift in the understanding of acne pathogenesis.
The reason i think this is because, before a new theory takes hold, the people with the illness notice that they have many things in common, (i.e the signs of histadelia..that have been posted early in this thread and that redshoes has added to) and scientists begin to notice seemingly unrelated associations with acne, such as zinc deficiency, refined carbohydrates, candiasis, stress and toxin overload, and of course HISTADELIA
.....the problem is that all current theories (the paradigm) about acne-genesis dont explain why all of these things separately can cause acne....
But this new theory Shows the missing link, ALL OF THESE THINGS CAUSE AN IMBALANCE IN the immune system
We need to do more research however...
1).The relationship of this theory to hormonal imbalance..ie is a hormonal imbalance a cause, or an effect of the immune imbalance...?
2). How the above factors can cause the immune imbalance
3).How immune imbalance affects other known areas of acne-genesis, such as PPARs, Insulin resistance..what is the relationship?
4). the cause of histadelia...we know that histadelia is a main contibutor to Th2:th1 imbalance, but what else can be done?
5). Other possible therapies ?
Also in responce to the post by 'freerider' who said:
Perilla Seed Extract has been used for immune system balancing. Maybe it will have a positive effect on acne. Here's a list I found of what perilla seed extract supposedly does:
• Suppress T helper Th2-type cytokine production, particularly interleukins 4, 5, 6, and 10 reducing inflammation
• Encourage Th1-type cytokines reducing the allergic response
• Suppress IgE production reducing the immediate allergic response
• Inhibit the overproduction of TNF-alpha reducing inflammation and allergies
• Inhibit histamine release from mast cells responsible for allergic symptoms – a natural anti-histamine effect.
• Inhibit the breakdown of arachidonic acid into inflammatory leukotrienes
I have since ordered perilla seed, and will try it out, see it is any good, (though when i ordered it i actually had some acne, so now it will be hard to tell if its working, not that im complaining!)
BUT another interesting piece of research is that if perilla seed rebalances Th2:Th1, then this decreases inflammatory leuckotriene production, this could provide the link with PPARs....
Obviously i dont wish to bore you to death... but a while ago a study was published showing that a drug called ZILEUTON
, (which is a LOX-5 antagonist).........
Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.
Zouboulis ChC, Saborowski A, Boschnakow A.
Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany. [email protected]
BACKGROUND: Zileuton, a 5-lipoxygenase inhibitor, reduces the number of inflammatory lesions in moderate acne and inhibits the synthesis of sebaceous lipids. OBJECTIVE: To detect whether zileuton directly reduces sebum synthesis. METHODS: A 40-year-old female with mild disseminated sebaceous gland hyperplasia and seborrhea was treated with zileuton 4 x 600 mg/day over 2 weeks, was followed-up for 6 weeks after discontinuation of zileuton and was re-treated with low-dose isotretinoin 10 mg/2nd day over 5 weeks. Casual skin surface lipids and sebum synthesis were determined. RESULTS: Under treatment with zileuton increased casual skin surface lipids were normalized and synthesis of facial sebum was decreased. Six weeks after discontinuation of treatment casual skin surface lipids were increased again and synthesis of sebum returned to baseline. Subsequent low-dose isotretinoin treatment led to similar changes of casual skin surface lipids and sebum synthesis with zileuton already after 2 weeks. CONCLUSION: Zileuton directly inhibits sebum synthesis in a transient manner with a potency similar to low-dose isotretinoin at least in our patient.
This study is afollow up to a previous study showing the same thing...i have researched this and found that...the normal products of LOX-5 act on PPARs
in the skin (sebocytes and keratinocytes) to increase the production of sebum and keratin...thus causing acne...The research by freerider suggests that Th2:Th1 imbalance causes increased production of the LOX-5 metabolites (ie increased activity of LOX-5)..
so instead of giving Zileuton to inhibit LOX-5, which works...we can simply try to re-address the immune imbalance (an imbalance that is favored by modern western living)...ie with H2 antagonists and perilla seed (maybe?) The task now is what else can re-set the balance?
One last point that redshoes brought up is that histadelics, are low-methylators
. This is a fascinating development, because methylation is such a vital process in the body, and may infact be the cause of the high levels of histamine (because histamine is de-activated by methylation)....What are the other efects of low-methylation? This is an urgent question that needs addressing?