Discussions that mention vasotec

High & Low Blood Pressure board


Mamzelle,

The side effects:
Risk is there for ALL drugs. Most drugs even carry a risk for FATAL anaphylactoid reactions...we just cannot assume the worst. Less than 1% means that more than 99 people out of a hundred will nto suffer any particular side effect. If we DO assume the worst, then there are no drugs that we can take, NONE!

How long do the drugs last:
It depends on the method and speed of metabolism. It's usually stated as a half life or the number of hours a particular drug takes to eliminate half of itself from our system. Picture a curve that goes up fast and comes down over time. A smaller dose would be a parallel curve at a lower level. If there is a certain blood level that is only minimally effective, then the lower dose will reach that first. So there is both a lower effect at all times of the day with the lower dosage AND an earlier point when the lower dosage will reach the level deemed "ineffective."

Drugs are usually made Time Release when their regular formulations dissipate in only a few hours. There seems to be something desirous in the medical community for once a day dosing. (I guess they assume all patients are too stupid to do something twice or thrice. :rolleyes: )

Try something:
Since you can take 3.75 mg. of enalapril without problems, why not try the 5 mg. again. Maybe you can tolerate it now? (Personally I hate the stuff because I coughed for 6 months on it!) As soon as you get the tickly cough, stop!

Not to scare you but just to ampliify what I mean about the ubiquitousness of side effects:
From Merck's prescribing information for Vasotec (enalapril):
[QUOTE]Skin: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, pemphigus, herpes zoster, erythema multiforme, urticaria, pruritus, alopecia, flushing, diaphoresis, photosensitivity.
See what I mean!