I posted a previous question about amitriptyline and vicodin. Here's another concern I have. I read somewhere that vicodin reduces the amount of endorphins in your brain while elavil is supposed to increase the endorphins. I wasn't sure why my NS didn't want me taking vicodin and now I wonder if this is the reason. The problem is the pain is a problem without the vicodin. Kind of a catch 22 I guess. Anyone have any other info on this subject?