I just started Vyvanse about 2 weeks ago. I'm on 70mg and it works GREAT for about 6 hours. After that, well, it kind of poops out. Before Vyvanse, I've tried Ritalin, Strattera, and Focalin XR. I was on Focalin XR 20 mg twice a day, which worked OK, but Ritalin has always worked best. I never know when the other medications are going to wear off, and with Ritalin, at least I know I have a 2 1/2 hour window in which to focus and get work done. Anyway, the Vyvanse is working OK, but I'm thinking of asking my doctor to either split the dosage or go on it twice a day as a did with the Focalin XR. I took an extra one tonight and so far, I'm focusing great. I guess I have quite the case of ADHD! I was only diagnosed at age 19, when I was a sophomore in college. It was suspected before, but was "ruled out" because I have a high IQ. (This was 10+ years ago--luckily it's been realized that intelligent people can have so-called learning disabilities!) I also have severe OCD, for which I take 300mg of Luvox a day, and Bipolar disorder, for which I take Abilify. Hope this post helps answer someone's questions! Good luck to everyone, I know dealing with ADHD isn't easy.