Discussions that mention zaroxolyn

High & Low Blood Pressure board


007,
Welcome to the boards :wave:

Well.
Firstly it certainly seems that your physician/s have covered and ruled out the possibility of secondary causes of your hypertension.
There are some alternative med combos you may try, but when hypertension persists on a 3-drug regimen it is also critical to address your weight and sodium intake. Your doc should be giving you a VERY hard time on this (to the point where you wanna kill him for nagging!:D

If you have the willpower, the Dash Diet is most certainly worth a shot.

By the way, are you on any other medications, even over-the-counter? As you probably know, there are many...even prescription meds, that can interfere with blood pressure control. If you are taking anything else, let us know.

Usually with "resistant" hypertension, the protocol would be to try, as your doc is trying now, a 3-drug regimen.

JUST LIKE CHOOSING FROM A CHINESE MENU (LOL)
it is suggested to try:

1.ORAL DIURETIC:
Equivalent to 25 mg of hydrochlorothiazide (Esidrix, HydroDIURIL, Oretic) or chlorthalidone (Hygroton) or

Equivalent to furosemide (Lasix), 320 mg/day, or metolazone (Zaroxolyn), 10 mg/day (if serum creatinine > 2.5 mg/dL)

plus

2.SYMPATHETIC INHIBITOR like a..
Beta blocker (equivalent to propranolol [Inderal], 320 mg/day, or atenolol [Tenormin], 100 mg/day) or

Clonidine HCl (Catapres), 0.6 mg/day, or

Prazosin (Minipress), 20 mg/day, or

Methyldopa (Aldomet), 2 g/day

or

Another agent like:
An ACE inhibitor(equivalent to captopril [Capoten], 200 mg/day, or benazepril HCl [Lotensin], 40 mg/day) or

An Angiotensin II blocker (ARB) such as Cozaar, Diovan, Benicar...etc

or

A Calcium channel blocker

plus


3. A DIRECT VASODILATOR such as Hydralazine HCl or minoxodil.

Docs often try what you are on now....instead of the direct vasodilator, they prescribe a diuretic with two drugs from group 2 . In your case, you're now on Group 2's beta blocker and an ACE inhibitor.

The next step might be to discuss the possibility of substituting either the ACE inhibitor (Altace) or the beta blocker (metoprolol) with a calcium channel blocker.

Confusing enough yet???

zuzu xxx