My husband is 67, had one heart bypass in 1991, had Pacemaker/Defibrillator inserted in 2003 and takes several medications. He was sent to a kidney specialist in 2003, who took him off Hyzaar, saying it was damaging his kidneys, and put him on Doxazosin 4 mg.(Cardura) for bp. The problem with this medication is that it causes his legs and middle to swell and he has shortness of breath. For this problem, the Dr. prescribed Zaroxolyn (2.5 mg.) which, for him is a very powerful drug. After just one pill (which he takes when he feels he absolutely needs it - he is afraid to take it regularly) his Potassium level can plummet, so he takes extra potassium.This is guesswork too- we are constantly refining the dosage. If potassium & other electrolytes get too low he gets "zapped" by his defibrillator and he is anxious at times wondering if this is going to happen! He is now getting his potassium level checked every week to "stay on top" of the situation. This swelling started when he was put on Doxazosin and we do not want to go back to something harmful for his kidneys, but we wish there was something else out there for him!In addition to the drugs aforementioned, he takes daily: ALLOPURINOL 200 MG,AMIODARONE 200 MG, DEMADEX 60 MG, METOPROLOL 100 MG, PLAVIX 75 MG,POTASSIUM 60 MG Will appreciate all replies. Thank you.