My husband took Zetia for about a year. The longer he took Zetia the more I noticed little things, then big things but did not relate it to the Zetia. One day we were talking and he told me he had been off and on at 3 month intervals. Hmmm....I began to put two and two together and it was when he was off Zetia he was acting normal and while on Zetia it was another story. I noticed it more in his driving. While driving he sat looking ahead with a somber expression (like he had lost his last friend), oblivous to his surroundings, aggressive driver, tailgaiter, irritable, no patience with other drivers and would even race to keep drivers from cutting in (with me screaming at him to get off the accelerator (in town), I almost had to take dangerous measures to stop him). He was irritable at home too, so different and a total contrast to his normal laid back personality.
He would order things via mail and have no recollection of doing so. He went to the bank to have a gift letter sent to our son's morgatage company and he gave the bank person a note with the address and had a charity listed. Hmmm...I got calls from the morgtgage company and after talking to the bank learned what he had done. The bank person told me what he gave her and she apparently was just being nice to this elderly man and did what he requested. This was a shake up to me, a man handling banking while being in a terrible mental state.
He stopped Zetia. After Zetia was out of his system in a few months he returned to his old self, even his cousin commented to him about how much better he looked. I now have my husband back mentally.
No, it did not lower his cholesterol. He has been following my diabetic diet and that has helped lower his numbers.