Discussions that mention zoledronic

Osteoporosis board


An experimental treatment for bone-thinning osteoporosis appears to prevent spine and hip fractures even though it is given only once a year, eliminating the need for a strict daily pill regimen, preliminary data show.

Reclast, given as an annual, 15-minute infusion, reduced risk of new spine fractures by 70 percent and of hip fractures by 40 percent, according to data supplied by maker Novartis Pharmaceuticals Corp. The drug, chemically known as zoledronic acid, also reduced the risk of fractures elsewhere, according to a just-completed, international study of 7,736 postmenopausal women with osteoporosis.

Side effects were generally minor and short-lived, said Novartis, of East Hanover, N.J.

The data, from final-stage human testing, was presented Saturday at the annual meeting of the American Society of Bone and Mineral Research in Philadelphia.

"This is very good news," said Dr. Ethel Siris (SEYE' riss), president of the National Osteoporosis Foundation and director of the Osteoporosis Center at Columbia University.

I just read this information and was wondering if anyone else had heard about this new experimental drug, it certainly gives alot of hope, also verifies how competitive the drug companies are in finding new ways to combat osteoporosis. I now understand when I read some of the postings that comment on waiting for a new breakthrough. Many of you probably already know about this but this was my first time reading about it. Once a year injection sounds to good to be true. blessings to all wildflowers
Those results are certainly encouraging.

The bad news: zoledronic acid is a bisphosphonate, so it may cause the same problems as the other bisphosphonates.
I think I posted this a while back, but here goes again. Some of the bisphosphonates have a short half-life (just because it is effective for a long time does not mean that the drug, in its original form, stays in your system that long):
Bisphosphonate Estimated Half Life
A partial list
Boniva = 4.6-15.3 hrs for IV 2mg after 2 hrs (IV and Oral)
Boniva = 5 - 25.5 hrs for IV 4mg after 2 hrs (IV and Oral)
Bonefos = 13 hrs for IV (IV and Oral)
Aredia = 28 +/- hrs (IV and Oral)
Zometa = 146 hrs (IV)
Actonel = 480 hrs (Oral)
Fosamax = 10 years (Oral)

Zometa is zoledronic acid.

As you can see, the only bisphosphonate with a truly horrendous half life is Fosamax.