i have been on zoloft for exactly a week...and i know its too soon to tell a difference...but do they seem to make your symptoms worse for the first few weeks and if so..how long does this last..i have panic disorder and depression and sometimes it just feels like i really cant take much more....im currently taking 50 mgs of the zoloft at bedtime and .50 xanax three times a day but sometimes it feels like i wanna jump out of my skin