Discussions that mention zoloft

Depression board


I've been clinically depressed for several years now. I tried several AD's with no luck, paxil, prozac, wellbutrin, celexa, zoloft, and finally effexor xr helped at the low dose of 75mg. Well about a year ago it starting to lose it's effectiveness. I saw someone and was diagnosed at the time with major depression recurrent without pyschotic features, needing a possible change in medicine and needing to rule out bipolar because it runs in my family. Well this month I went to a pdoc and he diagnosed me as bipolar II. Which I still really don't accept. Though I did have one mania episode in my life. It was 5 years ago and lasted about a year. First time it ever happened and it has never happened again. Most of the time I am depressed, sometimes severely, just existing. By this time I am up to 150mg of effexor xr and 300 of wellbutrin which I didn't see any difference so the pdoc took me off of wellbutrin and left me on effexor saying tho there were better meds that he didn't want to change too much at once. He put me on topamax. 25mg first week and was to increase 25mg for 4weeks up to 100mg. Well I only made it two weeks up to 50mg. I was so severely depressed last night, I don't think I would have cared if I'd have been on a plane that was crashing. The lowest I've been in so long. I know it was the topamax causing it, it worsened every day. And as the day went on by nightfall it was horrible. SO today I left word with my doc and he called back and of course took me off of the topamax. (I was going to stop it regardless of what he said) I see him again in 2 weeks so he just said to leave it at that till I see him again. I feel so hopeless. Like I will NEVER feel happiness again. Does anyone have any ideas as to what could possibly help me?? I see here how everyone hates effexor, and I know how bad the withdrawl is, I had to stop it when I was pregnant in '01. Not sure if I'll ever stop taking it due to that. Maybe I need a higher dose? I don't think I need a mood stabilizer, esp. not one for mania! I need a GOOD AD. HELP! God bless you all and best of luck to everyone here. Thank you for listening and offering any experience you may have. :angel:
Quote from needmylifeback:
I've been clinically depressed for several years now. I tried several AD's with no luck, paxil, prozac, wellbutrin, celexa, zoloft, and finally effexor xr helped at the low dose of 75mg. Well about a year ago it starting to lose it's effectiveness. I saw someone and was diagnosed at the time with major depression recurrent without pyschotic features, needing a possible change in medicine and needing to rule out bipolar because it runs in my family. Well this month I went to a pdoc and he diagnosed me as bipolar II. Which I still really don't accept. Though I did have one mania episode in my life. It was 5 years ago and lasted about a year. First time it ever happened and it has never happened again. Most of the time I am depressed, sometimes severely, just existing. By this time I am up to 150mg of effexor xr and 300 of wellbutrin which I didn't see any difference so the pdoc took me off of wellbutrin and left me on effexor saying tho there were better meds that he didn't want to change too much at once. He put me on topamax. 25mg first week and was to increase 25mg for 4weeks up to 100mg. Well I only made it two weeks up to 50mg. I was so severely depressed last night, I don't think I would have cared if I'd have been on a plane that was crashing. The lowest I've been in so long. I know it was the topamax causing it, it worsened every day. And as the day went on by nightfall it was horrible. SO today I left word with my doc and he called back and of course took me off of the topamax. (I was going to stop it regardless of what he said) I see him again in 2 weeks so he just said to leave it at that till I see him again. I feel so hopeless. Like I will NEVER feel happiness again. Does anyone have any ideas as to what could possibly help me?? I see here how everyone hates effexor, and I know how bad the withdrawl is, I had to stop it when I was pregnant in '01. Not sure if I'll ever stop taking it due to that. Maybe I need a higher dose? I don't think I need a mood stabilizer, esp. not one for mania! I need a GOOD AD. HELP! God bless you all and best of luck to everyone here. Thank you for listening and offering any experience you may have. :angel:


That episode of mania may have been caused by one or all of the AD's you have taken; mania is a side effect of SSri's but the claim is that it only happens to people who may have latent bi-polar..... I think that's probably not true, since we all have different reactions to drugs, chemicals, allergens, etc. I think it's just that some people just have adverse reactions to SSRi's just like anything else!

The "unmasking" of bi-polar when one is on an AD cracks me up. If the drug causes mania, it causes mania, and some people have different sensitivities to drugs, so that doesn't mean the person is manic-depressive or bi-polar.

Do you ever hear of a drug "unmasking" diabetes or cancer? Ridiculous.

There is one person I talk to on this board who was told that very thing, but funny how when she tapered down her AD that the mania completely disappeared!! :eek:

On the subject of depression, if you want natural relief, eat alot of dairy, eggs and meat, in other words high quality protein because that's what breaks down into amino acids and those make serotonin and other neuros. It does take some starch(complex carbs) to complete the process, or even something simple like orange juice. B- vitamins are also important to the process.

There were also studies that fish oil greatly relieved depression. Omega 3's are brain-healing.
I've also had experience of mania on SSRI's. When I was taking Zoloft it was the worst experience for me. I really thought I was going to have to be put in the hospital. My mom kept telling me to get off the Zoloft, but I didn't understand, the medicine was supposed to help me. Finally I came to my senses and got off of it. That was the one and only time I've experienced an episode of mania, and that was 5 years ago as well.
Quote from jas1980:
I've also had experience of mania on SSRI's. When I was taking Zoloft it was the worst experience for me. I really thought I was going to have to be put in the hospital. My mom kept telling me to get off the Zoloft, but I didn't understand, the medicine was supposed to help me. Finally I came to my senses and got off of it. That was the one and only time I've experienced an episode of mania, and that was 5 years ago as well.


This is quite a normal thing, because we are not taught medicine is bad for us. Well, since we cant' confirm such an alleged biological illness like clinical depression with any biological test or measure, the medication is really more like a controlling drug, not real medicine, and in that case could even be harmful.

I went through the same thing with benzos, I thought it was medicine intil I found out they were really what is on the street as "downers", a real mind drug, an anesthetic, a tranquilizer. Imagine my shock, since I never tried drugs, drank alcohol or smoked. And I developed tolerance big time. In other words, I had become an accidental addict despite never upping my dosages.

I had to go through a couple of years of protracted withdrawals(this is most common with benzos, not usual for AD's however) before feeling good and being able to sleep decently again.

All because nobody told me my intial problem, a reaction to codiene for a cold, was normal and would pass. Instead, I was given worse drugs and at one time deemed depressed.....given the liver-killing Serzone but luckily I didn't take it long because it made me throw up every day.

So, needless to say, when it comes to benzos and Ad's I've read up on them and it's a stretch if you ask me to call them "medications". Psychoactive mood drugs is much more accurate...