I was watching Discovery Health and there was a bit on anti-depressants. They were saying that drugs like Zoloft, Prozac etc.. may interfere with the blood's ability to clot. Normally I wouldn't care, but I am having surgery and I am on Zoloft as well as Wellbutrin (same drug class). I called my dr but they have yet to call me back to let me know if I need to stop taking it. I doubt it really causes too much trouble or it would be all over the news, but it is something to think about, just in case. Anyone else heard this?