If you lose sex drive from your AD, that certainly is a different side effect than I got from Zoloft. I went on Zoloft a few months ago and since then I feel like a hot mama all the time. I'd had zero interest in men since my husband's death 3½ years ago, and had a low sex drive all my life. But now on Zoloft I feel like more of a hot mama than I ever did in my teens or 20s. In fact, I have recently started a relationship with a very hot 40-year-old man. I'm 65.