Discussions that mention zoloft

Addiction & Recovery board


I don't have any direct experience with Tramadol, but from what I've read it's supposed to act similarly to Selective Serotonin Reuptake Inhibitors (SSRI) in addition to its opiate agonist properties, e.g. it effects serotonin levels in the brain. The SSRI class (think Zoloft, Paxil) has long term withdrawal side effects - (which I have experienced) - which include a sort of "brain shock", very disconcerting. I would not be surprised if Tramadol is having a similar effect after really long term use. Just a guess. It's probably worth talking to your doctor about.

Best of luck,

Raz