Discussions that mention zometa

Osteoporosis board


Hi Hypatia: Unfortunately Reclast is a bisphosphonate, and one of the stronger ones. It's been marketed before as Zometa for cancer treatment and used for Pagets disease as well. It has been included in the class action suit against bisphosphonates and Merck. It's also one of the nitrogenous ones that are really strong:(


Here's just a short list of bisphosphonates to date: etidronate (Didronel), pamidronate (Aredia), alendronate (Fosamax), risedronate (Actonel), zoledronate (Zometa or Reclast), ibandronate (Boniva)


So sorry if you were looking for a non bisphosphonate iv drug. So far all the iv drugs are stronger forms of the oral bisphos's. Maybe in the future there will be something other than bisphos's but right now we are stuck with them.
:wave:
Hi All: I don't know if you all have read about the "Dear Dr." letter that was sent out in 2004 by Novartis regarding Osteonecrosis of the Jaw, but I thought you might like to read it. According to this letter and another from an Oncology society, Novartis at least, has known about this disease since 2003. Novartis' main concern is cancer patients taking the stronger iv form of Zometa, but this problem applies to all the drugs in this class. If you read the Annals of Internal Med article, you'll see the actual figures in that case of iv use v oral use. Then there is the argument about cancer v osteoporosis and treatments of chemo, radiation, and corticosteroids. I hope I haven't bummed every one out, but at least the ray of hope is the small numbers of oral users with the disease. Unfortunately that doesn't help anyone dealing with it in that group of people, so for anyone that is dealing with this horrible disease, you're in my prayers.

Here's the letter:

[url]http://www.fda.gov/medwatch/SAFETY/2004/ZometaHCP.pdf[/url]