Discussions that mention zometa

Osteoporosis board


Hi everyone. Finished chemo and radiation. Walked five miles at least four times a week throughout it all. Again exercise helped me hold it together. Still doing herceptin evy 3 wks, no biggy. Feeling great. Dr. pushing for me to get zometa i.v. twice a year for three years. Says it will help stop the cancer from coming back. I know there were studies for this with pre-menopausal women. But I am post, and the studies are still underway. Also the old jaw necrosis se freaks me out, but so does the cancer coming back. Am going to speak with an expert dentist, who believes this se is overblown. Then I will make a decision. Just was wondering if anyone here knows anything about zometa? Would love to hear the pros and the cons.
Tomato Juice-Congratulations with accomplishing all that you have with your surgery, treatment and through that maintaining your walking routine !!!!!!!:jester: I am so glad to hear that you feel great!It must have helped so much to continue with your walking. There is something about walking that is so freeing. Moving through space, by your own locomotion, it just feels good on so many levels. Sometimes when I am walking, I feel like I am about ready to take off..... This happens more often where I can walk miles and miles with no obstacles and I feel like I could just walk right into the sky. Do you ever get that feeling in nyc? Maybe near the waterfront? About the zometa I cannot give you an answer either. I feel for you faced with this medical decision, but I know that you will gather your information and courageously proceed. I have read that at the Fred Hutchinson, Seattle Cancer Care Alliance-as part of a research study , women who were being treated for breast cancer were given denosumab. I wonder if you would have this option available to you? And, I do not know how it compares to zometa? It is not a bisphosphonate, to my understanding. Could you remind me what your t-scores were?? I do know that there are some formidable osteoporosis experts in NYC. One of them is Dr. Bilezikian (sp?) and another is a woman doctor who has started an osteoporosis clinic at one of the major medical centers. Apparently it was endowed by one of her patients. If you want me to pinpoint more info on either of these people I will do so. Perhaps consulting with an osteo expert and being followed by an osteo expert would be a good way to go at this time. And, it could possibly lighten some of the load about this decision that you need to make. I think Dr. B is at Columbia Presbyterian. He is a major world class osteo expert. Let me know if you want info on the woman dr. I could probably find it pretty easily.
I second Phyllis' motion-please do not be such a stranger around here! :)
Hi TomateJuice: It's so wonderful to hear how well you are doing... I agree that the walking is probably helping a lot. We all were wondering how you were doing. I'm glad that most of your treatment is behind you, so good luck on the remainder of the tx.

Zometa, Aclasta, and Reclast are all forms of zoledronic acid which is a bisphosphonate. Aclasta/Reclast are both marketed by Novartis, and Aclasta was the brand name given to ZA in Canada-Europe, and Reclast is the name for the US version which are both once yearly infusions for osteo.

Zometa, is also given as a infusion, but generally at a higher dose and more often depending on your Drs orders for cancer tx. You can check the milligrams on Zometa, to see how it compares to Reclast/Aclasta which is 5 mgs.

Densoumab isn’t a bisphosphonate, and I haven’t heard of ONJ with it either. Since denosumab is a monoclonal antibody, its main side effects are neoplasms and infections. This type of antibody is a biologic med so infections (though small in number in the studies) is something to consider. As you probably already know, neoplasms are any abnormal new growth of bodily tissue, or some call it a tumor. I prefer the abnormal growth definition, since tumor conjures up malignancy, which isn't always the case.

Here's a link on Denosumab even though that wasn't really what you asked about. It also several years old...

[url]http://content.nejm.org/cgi/content/full/354/8/821[/url]

Good luck with your decision, and keep us posted on your progress, I'm sure you'll do well.:angel::angel:
[QUOTE=tomatojuice;3778822]Hi everyone. Finished chemo and radiation. Walked five miles at least four times a week throughout it all. Again exercise helped me hold it together. Still doing herceptin evy 3 wks, no biggy. Feeling great. Dr. pushing for me to get zometa i.v. twice a year for three years. Says it will help stop the cancer from coming back. I know there were studies for this with pre-menopausal women. But I am post, and the studies are still underway. Also the old jaw necrosis se freaks me out, but so does the cancer coming back. Am going to speak with an expert dentist, who believes this se is overblown. Then I will make a decision. Just was wondering if anyone here knows anything about zometa? Would love to hear the pros and the cons.
Hi tomato juice, U R truly amazing with your 5 miles during all of this.
Hope U R feeling well. I am new to the boards. I saw your post about zometa. I would like to know what your decision was on zometa.
A postmena. friend also was recommended to take famera and zometa (getting rid of erimedex, hurts the bones too much) what was your decision on the zometa. If U R taking it; any side effects? I appreciate your input
Respectfully and in awe of your fight
Just
Hi Justiopenia....I decided not to take the zometa. Mostly due to the possible side effects(mostly jaw necrosis). Also the fact that no trials were done on post menopausal women. I am all finished with my cancere treatments. And I am really glad I chose to not have the zometa, because I am having two implants next month. And the doctors would have not done the surgery if I had been on any biophosphates. Good luck to you and your friend, in whatever you decide, as we all have different circumstances.
Thanks! It is a difficult decision. If you know of anyone that have used zometa, please LMK any side effects. Blessings
C
Lyn,
Reclast and Zometa are different. They use zometa for postmenapausal breast cancer survivors. Well, that is here in the states.
[QUOTE=justosteopenia;3980674]Lyn,
Reclast and Zometa are different. They use zometa for postmenapausal breast cancer survivors. Well, that is here in the states.

I also found out that is also called Aclasta. My Rheumy gave me an information sheet on Zometa and my general Dr gave me a sheet on Aclasta. Also Desserbloom on this thread has expanded on this too.
I asked just before the infusion went in what it was and was told "Zometa".

Zometa had just been approved for use in patients with osteo fracture by the Government Health Dept on the free medicine listing , the week in Australia that I had it. I was expecting to pay approx $800.

Keep asking questions... its your body and your decision.
Lyn x