hello- I am new to this site, and I have to say it's a big relief to know that I am not alone. I experience 'giant' hives first when I was 14, and then again 18. They came back a few weeks ago (I am now 41). When I was younger I went through every test and medication possible.
Prednisone is very helpful, but of course the doctor doesn't want me on it long-term due to side effects. I have also been taking Zyrtec twice a day. That helps some. If I don't taken anything i get giant hives all over my body, and my lips and tongue will swell at times. No one has ever been able to identify a cause. Very frustrating.
If you can take prednisone an ween yourself off, great!! I've read that the thyroid could be an issue as well. The Cortisone cream I don't use because it doesn't help much.
I've experienced acid reflux along with this as well, and will also take Zycam, which is very helpful. If past history tells me anything, this will go on for me for about 6-8 months before it goes away.